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Traceless Ligation of Cysteine Peptides Using Selective Deselenization

✍ Scribed by Dr. Norman Metanis; Prof. Ehud Keinan; Prof. Philip E. Dawson

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
390 KB
Volume
122
Category
Article
ISSN
0044-8249

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Synthetic proteins with unusual architecture are obtained through chemoselective ligation, a method based on the condensation of unprotected peptides under mild aqueous conditions. The last step of a new procedure leading to a tri-branched conjugate consists of the chemoselective ligation reaction b