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Trace element levels in the testes of thioacetamide-induced cirrhotic rats

โœ Scribed by H. Abul; T.C. Mathew; F. Abul; H. Al-Sayer; H. Dashti

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
101 KB
Volume
14
Category
Article
ISSN
0896-548X

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โœฆ Synopsis

Abstract

Masculine infertility disorders are related to changes in trace element metabolism in the testis. In this study, toxic effects of thioacetamide in trace element (zinc, copper, selenium, and manganese) levels in the serum and testis of rats were studied at 1โ€, 4โ€, 8โ€, and 12โ€week posttreatment duration. A decrease in serum zinc, copper, and selenium was noticed whereas the level of these trace elements in the testis was increased. Manganese showed an increase in both serum and testis in response to thioacetamide treatment. Changes in trace element level showed structural damage in different organs such as the liver, kidney, and spleen. Further studies are needed to establish the effect of the changes in the level of trace elements in the structure and function of the testes of thioacetamideโ€treated rats. J. Trace Elem. Exp. Med. 14:383โ€“392, 2001. ยฉ 2001 Wileyโ€Liss, Inc.

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