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TPAP-Catalyzed Direct Oxidation of Primary Alcohols to Carboxylic Acids through Stabilized Aldehyde Hydrates

✍ Scribed by Stark, Christian B. W.; Schmidt, Andrea-Katharina C.


Book ID
115439246
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
831 KB
Volume
13
Category
Article
ISSN
1523-7060

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A novel CrO~ catalyzed oxidation of primary alcohols to the carboxylic acids is reported. The oxidation proceeds smoothly with only 1-2 tool % of CrO 3 and 2.5 equivalents of H~IO 6 in wet MeCN to give the carboxylic acids in excellent yield. No significant racemization is observed for alcohols with