TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-α and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment

TPA-enhanced invasion of matrigel associ

TPA-enhanced invasion of matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1

✍ Kazuki Nabeshima; Naoto Komada; Jun-Ichi Kishi; Hiroyuki Koita; Teruhiko Inoue; 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 952 KB

We previously found that the enhanced activity to invade Matrigel upon stimulation with 12-0-tetradecanoylphorbol-13acetate (TPA) was one of the major properties of a highly metastatic variant (L-10) of a human rectal adenocarcinoma cell line RCM-I. To clarify the mechanism of this enhancement, we e