The p53 gene (TP53) is mutated in numerous human cancers. We have used it as a molecular target to characterize the induction of mutations in human skin cancers. About 50% of all skin cancers in normal individuals exhibit p53 mutations. This frequency rises to 90% in skin cancers of patients with th
TP53promoter methylation in human gliomas
β Scribed by Vishwa Jeet Amatya; Ulrike Naumann; Michael Weller; Hiroko Ohgaki
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 393 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0001-6322
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Manipulation of the mouse genome allows emulation of the genetic defects that give rise to human cancers and evaluation of the cooperating nature of different mutations in the transformation of distinct cell types. Here we review the generation of mice with specific missense mutations in p53 (TP53)
Analysis of the literature reporting p53 mutations shows that 8% of report display typographical mistakes with a notable increase in recent years. These errors are sometimes isolated, but in some cases, they concern several or even all mutations described in a single article. Furthermore, some works
The transcription of the DeltaN133p53 isoform of the TP53 gene is controlled by an internal promoter region (IPR) containing eight polymorphisms in 11 common haplotypes, following a resequencing of 47 Caucasians. We assayed the functional effects of the commonest six haplotypes on the promoter activ