TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors
β Scribed by Kanokkan Bumroongkit; Bruce Rannala; Patrinee Traisathit; Metawee Srikummool; Yannawan Wongchai; Daoroong Kangwanpong
- Book ID
- 113513363
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 264 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0165-4608
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Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast t
## Abstract Single nucleotide polymorphisms (SNPs) were searched for in 36 genes involved in diverse DNA repair pathways, and 50 nonsynonymous (associated with amino acid changes) SNPs identified were assessed for associations with lung cancer risk by a caseβcontrol study consisting of 752 adenocar