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1128 POSTER Mutations in CHEK2 and TP53 Genes in High-Risk Hereditary Breast and Ovarian Cancer Patients in the Czech Republic

✍ Scribed by I. Tichá; J. Stribrna; J. Soukupova; P. Pohlreich

Book ID: 117661265
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 40 KB
Volume: 47
Category: Article
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(11)70771-7

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## Communicated by Mark H. Paalman Germline mutations in breast cancer susceptibility genes, BRCA1 and BRCA2, are responsible for a substantial proportion of high-risk breast and breast/ovarian cancer families. To characterize the spectrum of BRCA1 and BRCA2 mutations, we screened Czech families w