## Communicated by Mark H. Paalman Germline mutations in breast cancer susceptibility genes, BRCA1 and BRCA2, are responsible for a substantial proportion of high-risk breast and breast/ovarian cancer families. To characterize the spectrum of BRCA1 and BRCA2 mutations, we screened Czech families w
1130 POSTER Spectrum of Mutations in BRCA1 and BRCA2 Genes in Families at High Risk of Breast and Ovarian Cancer in the Czech Republic
โ Scribed by P. Pohlreich; J. Stribrna; I. Ticha; J. Soukupova; J. Kotlas; A. Panczak
- Book ID
- 117661267
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 56 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0959-8049
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Germline mutations in BRCA1 and BRCA2 account for majority of hereditary breast and ovarian cancer. The complete coding sequence analysis of both genes was carried out in 197 breast/ovarian cancer patients from high-risk families and 53 patients with sporadic breast/ovarian cancer. In summary, 59 mu
The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo