TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas
✍ Scribed by Vítor Lima-Ramos; Luís Pacheco-Figueiredo; Sandra Costa; Fernando Pardal; Ana Silva; Júlia Amorim; José Manuel Lopes; Rui Manuel Reis
- Book ID
- 113513238
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 232 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0165-4608
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This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and wer
The original article to which this Erratum refers was published in Human Mutation 24: 21-34 (2004). Using a newly developed method-Arrayed Primer Extension (APEX) and direct sequencing of exon 10 and 11 to reanalyze for TP53 sequence alterations-13 new mutations were identified. In addition, a few