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TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas

✍ Scribed by Vítor Lima-Ramos; Luís Pacheco-Figueiredo; Sandra Costa; Fernando Pardal; Ana Silva; Júlia Amorim; José Manuel Lopes; Rui Manuel Reis


Book ID
113513238
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
232 KB
Volume
180
Category
Article
ISSN
0165-4608

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This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and wer

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