## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1–3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type
Toxoplasma gondii inhibits MHC class II expression in neural antigen-presenting cells by down-regulating the class II transactivator CIITA
✍ Scribed by Carsten G.K Lüder; Christine Lang; Mario Giraldo-Velasquez; Michaela Algner; Jens Gerdes; Uwe Gross
- Book ID
- 114137772
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 843 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0165-5728
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In order to develop an effective immunotherapy for hematological malignancies, we investigated the applicability of class II transactivator (CIITA), which had been demonstrated to regulate the expression of MHC class II (MHC-II) by assembling the transcription factors of MHC-II molecules, for immuno
The obligate intracellular protozoan parasite Toxoplasma gondii is able to establish persistent infections within human and animal hosts. We have shown recently that T. gondii downregulates IFN-+ -induced MHC class II expression in murine bone marrow-derived macrophages (BMM ¶ ). As shown in this st
## Abstract Malignant gliomas (MGs), lethal human central nervous system (CNS) neoplasms, contain tumor infiltrating lymphocytes (TIL). Although MHC class II molecules are frequently detected on MG cells, suggesting that they may be capable of antigen (Ag) presentation to CD4^+^ T cells, deficienci