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Differential expression of MHC class II molecules in highly metastatic breast cancer cells is mediated by the regulation of the CIITA transcription: Implication of CIITA in tumor and metastasis development

✍ Scribed by Bo Shi; Antònia Vinyals; Pedro Alia; Cristina Broceño; Feisong Chen; Marc Adrover; Carme Gelpi; Janet E. Price; Àngels Fabra

Book ID
116307060
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
729 KB
Volume
38
Category
Article
ISSN
1357-2725

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## Abstract In patients with cancer, DC express significantly lower amounts of MHC class II compared with those of normal individuals. However, the underlying mechanisms for this have not yet been fully defined. In the present study, we found that IL‐10 plays a major role in the tumor‐conditioned m