Toxicological evaluation of acetylated faba bean globulin

✍ Scribed by Schmandke, Horst; Plass, Roland; Lewerenz, Hans-Jochen; Bleyl, Dietmar W?R

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 104 KB
• Volume: 80
• Category: Article
• ISSN: 0022-5142
• DOI: 10.1002/(sici)1097-0010(20000101)80:1<109::aid-jsfa497>3.0.co;2-f

✦ Synopsis

Acetylated faba bean globulin (acVFG, acetylation degree 97%) was evaluated toxicologically in a subchronic feeding study and a female fertility test. Groups of male and female rats received acVFG in their diet at levels of 20, 40 and 80 g kg À1 for 3 months. Additional groups were fed a commercial diet or given food containing 38 or 75 g kg À1 casein. The subchronic toxicity study revealed growth retardation in both sexes at the 80 g kg À1 acVFG level. The food consumption was reduced in males at 40 and 80 g kg À1 acVFG and in females at 80 g kg À1 acVFG. Histopathological alterations in the ovaries were observed at dietary levels of 40 and 80 g kg À1 acVFG. Histopathological changes and decreases in the absolute and relative weight of the uterus were found in all groups fed acVFG. Therefore a no-observed-effect level (NOEL) was not derivable. Feeding females 80 g kg À1 acVFG resulted in diminished pre-implantation losses but increased post-implantation losses in the fertility study.