Halothane hepatotoxicity in glutathione
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Klaus-Peter Wilhelm; Maged Younes; Dieter Sellin; Claus-Peter Siegers
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Article
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1987
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John Wiley and Sons
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English
β 610 KB
Experimental models for halothane hepatotoxicity require microsomal enzyme induction by phenobarbital or triiodo-thyronine pretreatment and hypoxic conditions. The role of GSH in the metabolism of halothane, however, is still unclear. We therefore pretreated male rats with phorone to deplete hepatic