Toxicokinetics of acrylamide and glycidamide in B6C3F1 mice
β Scribed by Daniel R. Doerge; John F. Young; L. Patrice McDaniel; Nathan C. Twaddle; Mona I. Churchwell
- Book ID
- 113923421
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 329 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0041-008X
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## Abstract The oral and i.v. elimination kinetics were investigated for bromodichloroacetate (BDCA), a haloacetate found in drinking water. The BDCA was administered at a dose of 5, 20 and 100 mg kg^β1^ to B6C3F1 mice and appears to distribute to the total body water with a mean volume of distribu
## Abstract Acrylamide, a food contaminant, is carcinogenic in experimental animals, with both genotoxic and nongenotoxic pathways being proposed. To obtain information regarding mechanisms of acrylamide tumorigenesis, we compared the extent of DNA adduct formation and induction of micronuclei and