Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
✍ Scribed by Nathan C. Twaddle; L.Patrice McDaniel; Gonçalo Gamboa da Costa; Mona I. Churchwell; Frederick A. Beland; Daniel R. Doerge
- Book ID
- 116332947
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 174 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0304-3835
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Acrylamide levels of bakery products, e. g., bread and bread rolls, are usually below 100 microg/kg , often even below 50 microg/kg. Therefore, usual analytical methods which have an LOQ greater, not dbl equals 25 microg/kg are not sensitive enough for detailed investigations on acrylamide formation
## Abstract Acrylamide, a food contaminant, is carcinogenic in experimental animals, with both genotoxic and nongenotoxic pathways being proposed. To obtain information regarding mechanisms of acrylamide tumorigenesis, we compared the extent of DNA adduct formation and induction of micronuclei and