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Toxicokinetic Modeling of Dose-Dependent Formate Elimination in Rats:In Vivo–in VitroCorrelations Using the Perfused Rat Liver

✍ Scribed by Paul Damian; Otto G. Raabe


Book ID
112266126
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
165 KB
Volume
139
Category
Article
ISSN
0041-008X

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The kinetics of hepatic elimination of the high-clearance drug propranolol has been interpreted in a previous study from our laboratory, in which propranolol protein binding was varied, to conform to the venous equilibrium model. In another study by a different group, in which perfusate flow was var