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Toxicity of Soman after Repetitive Injection of Sublethal Doses in Rat

✍ Scribed by Sterri, Sigrun H. ;Lyngaas, Synnøve ;Fonnum, Frode


Book ID
114799762
Publisher
Wiley (Blackwell Publishing)
Year
2009
Weight
415 KB
Volume
46
Category
Article
ISSN
0001-6683

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Male Sprague-Dawley rats, injected with the irreversible acetylcholinesterase (AChE) inhibitor soman (pinacolyl methylphosphonofluoridate) 25 micrograms/kg sc, showed no signs of toxicity. Pretreatment with iso-OMPA (tetraisopropylpyrophosphoramide) 1 mg/kg sc 1 h before the soman administration, ca