Effects of repeated injection of sublethal doses of soman on behavior and on brain acetylcholine and choline concentrations in the rat
โ Scribed by Tsung-Ming Shih; David E. Lenz; Donald M. Maxwell
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 949 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0033-3158
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๐ SIMILAR VOLUMES
Brain microdialysis was used to determine whether systemic or local application of choline would modify the extracellular concentration of acetylcholine (ACh) in the nucleus accumbens (NAc) of freely moving rats. Supplemental choline given intraperitoneally or into the NAc of normal rats did not inc
## Abstract Recent reports suggest that oral choline supplement may alter the cerebral choline/creatine (Cho/Cr) ratio and might be used to treat neurodegenerative disorders of cholinergic transmission. Using both ^1^H and ^31^P MRS, we reexamined the Cho/Cr ratio and quantified cerebral choline an