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Toxicity of ifosfamide and its metabolite chloroacetaldehyde in cultured renal tubule cells

✍ Scribed by James Springate; Kenneth Chan; Hong Lu; Sherry Davies; Mary Taub


Book ID
107427661
Publisher
Society for In Vitro Biology
Year
1999
Tongue
English
Weight
448 KB
Volume
35
Category
Article
ISSN
1475-2689

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## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium‐dependent calpains and caspases. Calbindin‐D~28k~, a cytos