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Ifosfamide toxicity in cultured proximal renal tubule cells

✍ Scribed by James Springate; Mary Taub


Publisher
Springer
Year
2007
Tongue
English
Weight
287 KB
Volume
22
Category
Article
ISSN
0931-041X

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## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium‐dependent calpains and caspases. Calbindin‐D~28k~, a cytos