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Toxicity of antibiotics on cultured human skin fibroblasts

✍ Scribed by W. Byarugaba; H. W. Rüdiger; Thea Koske-Westphal; W. Wöhler; E. Passarge

Publisher
Springer
Year
1975
Tongue
English
Weight
299 KB
Volume
28
Category
Article
ISSN
0340-6717

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✦ Synopsis

Human diploid fibroblasts cultured in Dulbecco's Modified Eagle's medium (DME) were exposed to different concentrations of 15 antibiotics to determine the limiting toxic concentration. The number of cells surviving after antibiotic treatment was given as the index of toxicity. No visible chromosomal damage could be detected when half the maximal toxic concentration was applied. The maximum limiting concentration was found to be the same for both the preconfluent and postconfluent phases.

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