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Effects of glucocorticosteroids on cultured human skin fibroblasts

✍ Scribed by Maria Ponec; Corry Haas; Bernard N. Bachra; Machiel K. Polano

Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
520 KB
Volume
265
Category
Article
ISSN
0340-3696

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✦ Synopsis

An immediate depression of the rate of cell proliferation occurred upon addition of glucocorticosteroids to cultures of human skin fibroblasts in the early growth stages. A reduced sensitivity or even insensitivity of the fibroblasts to growth inhibition inhibition was found upon the addition of the steroids at later stages of cell growth, when the cell density has increased. The inhibition in the early growth stages is transient and is most pronounced if the cultured medium is not renewed. This transient inhibition is not due to the development of steroid-resistant cell lines, and resembles the effect called tachyphylaxis, as is also observed in vasoconstriction tests.

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