Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice
โ Scribed by P. C. Chan; G. D. Hill; G. E. Kissling; A. Nyska
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 96 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0340-5761
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๐ SIMILAR VOLUMES
Glycidol, a simple aliphatic epoxide, was administered by gavage in water to groups of male and female F344/N rats and B6C3F1 mice. Rats received 0, 37.5 or 75 mg kg-' and mice received 0, 25 or 50 mg kg-' daily, 5 days per week for 2 years. Exposure to glycidol was associated with dose-related incr
Toxicology and carcinogenesis studies of hydrochlorothiazide, a benzothiadiazide diuretic, were conducted by administering diets containing the drug to both sexes of F344 rats and B6C3F1 mice in S d a y , 13-week and 2-year studies. No rats died during the 15-day or 13-week studies at dietary concen
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