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Toxic effect of polyriboinosinic-polyribocytidylic acid on mouse hemopoietic stem cells

✍ Scribed by Pierre Jullien; Jaqueline de Maeyer-Guignard

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
555 KB
Volume
7
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Within a few hours following a single intraperitoneal injection of polyriboinosinic‐polyribocytidylic acid (poly I:poly C) into C3H/He mice, numbers of bone‐marrow and spleen‐colony‐forming cells are significantly decreased. The dose‐response curve obtained shows an exponential decrease of the surviving CFU with increasing amounts of poly I:poly C, up to 200 μg; with higher doses of poly I:poly C, no further decrease of CFU is observed. This suggests that poly I:poly C kills colony‐forming cells in replicating phase, and is devoid of activity on cells in resting phase. The lack of additive toxic effects observed when poly I:poly C and vinblastine sulfate are administred simultaneously is consistent with this hypothesis. The cytotoxic effect of the polynucleotide is related to its double‐strandedness and is not mediated by interferon present in the serum.

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