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Toxic effect of concomitant administration of cyclosporin A and acyclovir on renal function and morphology in rats

✍ Scribed by Jörg. Hannemann; Werner Wunderle; Tarik Yousif; Stefan Krüger; Karl Baumann

Book ID
105871498
Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
329 KB
Volume
71
Category
Article
ISSN
0340-5761

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Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.