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Toxic and hypericaemic effects of Opuntia megacantha extract in rats

✍ Scribed by Phillip Bwititi; Mika Zamurawo; George Mabhachi; N. Mashanga

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
39 KB
Volume
11
Category
Article
ISSN
0951-418X

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✦ Synopsis

The effect of O. megacantha extract on blood uric acid levels and other biochemical profiles were investigated over a 5 week period of giving rats an oral dose of 20 mg/100 g body weight of the extract daily. The results show that O. megacantha extract significantly lowered (p < 0.01) serum uric acid and increased renal excretion of uric acid by comparison with controls. Serum creatinine, AST (aspartate aminotransferase) and phosphate levels were significantly raised (p < 0.05) in the experimental group. However serum magnesium, calcium and ALP (alkaline phosphatase) were lowered (p < 0.05) in the same group by comparison with control rats. An increase (p < 0.05) in total water intake, an increase (p < 0.05) in total urinary uric acid excretion as well as a slight increase in total urine voided over the 5 week period were observed.

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