Towards the rehabilitation of the Mathews’ ‘dry’ hydrolysis reaction using microwave technology

✍ Scribed by Farid Chemat

• Book ID: 104251532
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 67 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01127-9

✦ Synopsis

The Mathews' reaction is a one-pot preparation of carboxylic acids from their corresponding nitriles or amides by a 'dry' hydrolysis with phthalic acid or anhydride in the absence of water and solvent. Excellent isolated yields and selectivity (up to 99%) were attained within short reaction times (typically, 30 minutes) when the reaction was performed under microwave heating.