✍ Scribed by Olga Juanes; Pilar Goya; Ana Martinez
No coin nor oath required. For personal study only.
Two different strategies for the synthesis of S‐Adenosyl‐L‐methionine liphophilic derivatives have been attempted. The first chemical direct modification performed on S‐adenosyl‐L‐methionine is described.
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Edited By Piet Herdewijn. Includes Bibliographical References And Index.
S-Adenosylmethionine (SAMe) has rapidly moved from being a methyl donor to a key metabolite that regulates hepatocyte growth, death, and differentiation. Biosynthesis of SAMe occurs in all mammalian cells as the first step in methionine catabolism in a reaction catalyzed by methionine adenosyltransf
Cation-exchange chromatography with sulfopropyl Sephadex was used to measure the levels of S-[methyl-3H]adenosyl-L-methionine synthesized by L1210 cells in vitro. Separation of S-[methyl-3H]adenosyl-L-methionine from [methyl-3H]methionine and other metabolites was achieved by stepwise elution with v