Towards development of T-cell vaccines

✍ Scribed by Constantin A. Bona; Sofia Casares; Teodor-D. Brumeanu

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 965 KB
• Volume: 19
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(98)80011-x

✦ Synopsis

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dward Jenner carried out the first successful human vaccination experiment only 200 years ago, demonstrating that the inoculation of a boy with crossreactive cowpox virus protected him against two successive infections with smallpox virus. Retrospectively, we know that Jenner created a T-cell vaccine. However, since then, the majority of efforts of vaccinologists has been directed primarily towards the preparation of vaccines able to elicit protective antibodies. Only in the past decade has sufficient progress been made in understanding the functions of T cells leading to the development of T-cell vaccines. Such vaccines Recent studies on the recognition of antigens by CD4 ' and CD8 ~ T cells have revealed new ways ot preparing efficient 7~cell vaccines. Here, Constantitt Botta attd Colh'CIp, ltcS discttss sc~c'ral approaches fi~r the development Of T-cell vaccines, with applications ranging from the induction of protective immuttity against intnwellular lnm~sites to the developntent Of thenlpeutic agents against autoimmum, disorders, allergic diseases and cancer. may prove beneficial for the development of immunotherapeutic agents against autoimmune disorders and cancer, as well as in the induction of protective immunity against infectious agents. ILI ,i, Vol. I 9 N o. 3 I 2 7