✦ LIBER ✦

Toward the development of DNA vaccines

✍ Scribed by Jeffrey B Ulmer; John J Donnelly; Margaret A Liu

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 631 KB
Volume: 7
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(96)80078-4

No coin nor oath required. For personal study only.

✦ Synopsis

DNA vaccination has proved to be a generally applicable technology in various preclinical animal models of infectious and noninfectious disease and several DNA vaccines have now entered phase I human clinical trials. It is too early to predict the effectiveness of DNA vaccines in humans and whether improved formulations of DNA vaccines will be required but several lines of investigation have suggested ways in which DNA vaccines may be improved, such as increases in expression, facilitation of DNA targeting or uptake, and enhancement of immune responses.

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