## Abstract Organic anion transporters (OAT) play essential roles in the body disposition of clinically important anionic drugs, including anti‐viral drugs, anti‐tumor drugs, antibiotics, anti‐hypertensives, and anti‐inflammatories. The activities of OATs are directly linked to drug toxicity and dr
Towards and Understanding of Organic Anion Transporters: Structure—Function Relationships.
✍ Scribed by Guofeng You
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 7 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Renal elimination of anionic drugs, xenobiotics, and toxins is necessary for the survival of mammalian species. This process is mediated by vectorial transport from blood to urine through the cooperative functions of specific transporters in the basolateral and apical membranes of the p
The organic anion transporting polypeptide (OATP) of the basolateral hepatocyte membrane mediates multispecific uptake of anionic and other amphipathic substrates from sinusoidal blood plasma. To investigate the mechanisms controlling OATP expression, the 5'-flanking region of the human OATP gene wa