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Towards a Practical and Efficient Copper-Catalyzed Trifluoromethylation of Aryl Halides

✍ Scribed by Schareina, Thomas; Wu, Xiao-Feng; Zapf, Alexander; Cotté, Alain; Gotta, Matthias; Beller, Matthias

Book ID
113080502
Publisher
Springer
Year
2012
Tongue
English
Weight
441 KB
Volume
55
Category
Article
ISSN
1022-5528

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An efficient copper-catalyzed coupling of aryl halides with imidazoles
✍ Ayumu Kiyomori; Jean-François Marcoux; Stephen L. Buchwald 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 230 KB

Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)2°benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 °C. Addition of 1,10-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylim