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An efficient copper-catalyzed coupling of aryl halides with imidazoles

✍ Scribed by Ayumu Kiyomori; Jean-François Marcoux; Stephen L. Buchwald

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
230 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)2°benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 °C. Addition of 1,10-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylimidazoles, were isolated in high yields.

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