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Toward the Synthesis of Reidispongiolide A: Stereocontrolled Synthesis of the C 17 −C 22 and C 23 −C 35 Degradation Fragments

✍ Scribed by Paterson, Ian; Ashton, Kate; Britton, Robert; Knust, Henner


Book ID
127069762
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
114 KB
Volume
5
Category
Article
ISSN
1523-7060

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Synthetic studies on reidispongiolide A,
✍ Satoshi Akiyama; Eisuke Toriihara; Kazushi Suzuki; Toshiaki Teruya; Kiyotake Sue 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 265 KB

The C11-C22 and C23-C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively.