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Synthetic studies on reidispongiolide A, an actin-depolymerizing marine macrolide: synthesis of C11–C22 and C23–C35 segments

✍ Scribed by Satoshi Akiyama; Eisuke Toriihara; Kazushi Suzuki; Toshiaki Teruya; Kiyotake Suenaga

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 265 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.06.075

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✦ Synopsis

The C11-C22 and C23-C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively.

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