Toward the gene(s) for Wiedemann-Beckwith syndrome and associated tumors in 11p15
✍ Scribed by I. Henry; V. Chéhensse; C. Boulevin; C. Jeanpierre; P. Little; C. Junien
- Book ID
- 119106233
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 129 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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The Beckwith-Wiedemann syndrome (BWS) is an overgrowth malformation syndrome that occurs with an incidence of 1:13,700 births. There is a striking incidence of childhood tumors found in BWS patients. Various lines of investigation have localized "imprinted" genes involved in BWS and associated child
## Abstract Beckwith–Wiedemann syndrome (BWS) is an overgrowth syndrome characterized by macrosomia, macroglossia, omphalocele, hemihyperplasia, and increased tumor risk. BWS can be associated with genetic and/or epigenetic alterations that modify imprinted gene expression on chromosome 11p15.5. So