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Molecular definition of the 11p15.5 region involved in Beckwith-Wiedemann syndrome and probably in predisposition to adrenocortical carcinoma

✍ Scribed by Isabelle Henry; Marc Jeanpierre; Philippe Couillin; Fernande Barichard; Jean-Louis Serre; Hubert Journel; Annie Lamouroux; Catherine Turleau; Jean Grouchy; Claudine Junien


Book ID
104700880
Publisher
Springer
Year
1989
Tongue
English
Weight
538 KB
Volume
81
Category
Article
ISSN
0340-6717

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Many human syndromes involve a loss of imprinting (LOI) due to a loss (LOM) or a gain of DNA methylation (GOM). Most LOI occur as mosaics and can therefore be difficult to detect with conventional methods. The human imprinted 11p15 region is crucial for the control of fetal growth, and LOI at this l