Toward Synthesis of α-Alkyl Amino Glycines (A3G), New Amino Acid Surrogates
✍ Scribed by Yaouancq, Loïc; René, Loïc; Tran Huu Dau, Marie-Elise; Badet, Bernard
- Book ID
- 126188746
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 60 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Alkylation / Oxazolines / anti-α-Alkyl α-hydroxy β-amino acids / Lithium dianion / Penicillin G acylase As part of an ongoing project concerning the synthesis of conditions, affording in quantitative yield the corresponding hydroxy amides. The starting (R)-3-amino-3-phenyl-enantiomerically pure α-hy
For the purpose of practical preparations of a variety of enantiomerically pure uncommon ¢x-amino acids, alkylations of the chiral glycine equivalent 5, which possesses axially chiral binaphthol as an auxiliary, with several electrophiles were investigated. The alkylation proceeded smoothly in satis
The highly stereoselective alkylation (% de=99.6 to 97.6) of a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described. Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding a-amino acids wi