Toward Re-expressing Tumor Suppressor Gene Maspin in Breast Cancer
β Scribed by Ming Zhang
- Book ID
- 117794025
- Publisher
- CIG Media Group, LP.
- Year
- 2002
- Tongue
- English
- Weight
- 49 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1526-8209
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Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most
## Abstract Loss of heterozygosity on the long arm of chromosome 16 is one of the most frequent genetic events in breast cancer, suggesting the presence of one or more classic tumorβsuppressor genes (TSGs). It has been shown that Eβcadherin is the TSG on 16q in lobular tumors. In a search for the t