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Total Synthesis ofrac-Silandrin, an Antihepatotoxic Flavanolignan

✍ Scribed by Antus, Sándor ;Baitz-Gács, Eszter ;Gottsegen, Agnes ;Kovács, Tibor ;Szunyog, József ;Tóth, Tamás S. ;Wagner, Hildebert

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 509 KB
Volume: 1993
Category: Article
ISSN: 0947-3440
DOI: 10.1002/jlac.199319930119

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✦ Synopsis

Abstract

The first synthesis of racemic silandrin (rac‐1), which shows significant antihepatotoxic activity, has been accomplished via the key intermediate 9 prepared from the readily available starting materials caffeic acid ethyl ester (4) and coniferyl alcohol (5).

📜 SIMILAR VOLUMES

Total Synthesis ofrac-Silyhermin and Its

Total Synthesis ofrac-Silyhermin and Its 2-Diastereomers of Potential Antihepatotoxic Activity

✍ Antus, Sándor ;Baitz-Gács, Eszter ;Gottsegen, Ágnes ;Seligmann, Otto ;Wagner, Hi 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 374 KB

## Abstract The first synthesis of racemic silyhermin (__rac__‐1a) and its 2‐diastereomers 1b (as a ca. 1:1 mixture) was accomplished by starting from caffeic acid ethyl ester and coniferyl alcohol.