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Total Synthesis of Tubulysin U and Its C-4 Epimer

✍ Scribed by Yang, Xiu-dong; Dong, Chang-ming; Chen, Jian; Ding, Ya-hui; Liu, Qi; Ma, Xiao-yan; Zhang, Quan; Chen, Yue

Book ID: 126999027
Publisher: John Wiley and Sons
Year: 2013
Tongue: English
Weight: 496 KB
Volume: 8
Category: Article
ISSN: 1861-4728
DOI: 10.1002/asia.201300051

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Tubulysins (1) are compounds of extraordinary potency, rapidly degrading the tubulin cytoskeleton, with tubulysin D being the most active tubulin-modifier known so far. [1,2] The tubulysins were first described by Höfle, Reichenbach, and co-workers in 2000. [3,4] Several representatives are active w