Total Synthesis of Tubulysin U and V
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Alexander Dömling; Barbara Beck; Uwe Eichelberger; Sukumar Sakamuri; Sanjay Meno
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Article
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2006
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John Wiley and Sons
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English
⚖ 125 KB
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Tubulysins (1) are compounds of extraordinary potency, rapidly degrading the tubulin cytoskeleton, with tubulysin D being the most active tubulin-modifier known so far. [1,2] The tubulysins were first described by Höfle, Reichenbach, and co-workers in 2000. [3,4] Several representatives are active w