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Total synthesis of topsentolide B2

✍ Scribed by Rodney A. Fernandes; Pullaiah Kattanguru

Book ID: 104098934
Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 332 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.02.014

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✦ Synopsis

A stereoselective total synthesis of topsentolide B 2 , a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield.

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