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Total synthesis of thienamycin: a new approach from aspartic acid
β Scribed by Paul J. Reider; Edward J.J. Grabowski
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 176 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Recently, Salzmann et al.' have reported a synthesis of thienamycin (1) in which the chirality at C5 was derived from L-aspartic acid (I_).
π SIMILAR VOLUMES
Regioselective reactions at the terminal double bond of the racemic azetidinone dienylether (4), provides a source of clavulanic acid and several analogues. We have recently reported la the first total synthesis of (t)-olavulenic acid (l), which relied upon the construction, double-bond isomerisati
The total synthesis of (-)-ot-Kainic Acid 1 has been accomplished using ethyl N-Bocpyroglutamate 2 as starting material. The isopropenyl appendage was achieved from the elimination of the dimethylcarbinol introduced at C-4 via an aldol condensation of the lactam enolate of 2 and acetone. The acetate