## Abstract The total synthesis of phytotoxic nonenolide herbarumin II (**1**) has been achieved by implementation of butane diacetal (BDA)‐desymmetrised glycolate building blocks. Three of the four stereogenic centres present in the key coupling fragments were generated from both enantiomeric form
Total Synthesis of the Phytotoxic Agent Herbarumin II Using Butane Diacetals of Glycolic Acid as Building Blocks.
✍ Scribed by Elena Diez; Darren J. Dixon; Steven V. Ley; Alessandra Polara; Felix Rodriguez
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 104 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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37 8C) and the mixture was filtered in a UltraFree MC 30 000 MWCO centrifugal filtration unit (Millipore) at 3500 g for 7 min at 37 8C. The concentration of free substrate in the filtrate was quantified by ICP-MS and the bound fraction was calculated as % bound ([total]-[free])/[total]. The proton T
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