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Total Synthesis of the Neuronal Cell-Protecting Carbazole Alkaloids Carbazomadurin A and ( S )-(+)-Carbazomadurin B

✍ Scribed by Hieda, Yuhzo; Choshi, Tominari; Fujioka, Haruto; Hibino, Satoshi


Book ID
125445327
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
677 KB
Volume
2013
Category
Article
ISSN
1434-193X

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A new total synthesis of the neuronal cell-protecting carbazole alkaloid carbazomadurin A is described. The key step was an allene-mediated electrocyclic reaction involving an indole [b]-bond for the construction of a highly substituted carbazole ring. The E-alkenyl side chain at the C1 position of

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Isolation and Structure Elucidation of Novel Neuronal Cell Protecting Substances, Carbazomadurins A and B Produced by Actinomadura madurae. -Ongoing screening for substances protecting central nervous system from glutamate toxicity leads to the discovery of the title compounds (I). Both substances