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ChemInform Abstract: Isolation and Structure Elucidation of Novel Neuronal Cell Protecting Substances, Carbazomadurins A and B Produced by Actinomadura madurae.

✍ Scribed by N. KOTODA; K. SHIN-YA; K. FURIHATA; Y. HAYAKAWA; H. SETO

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Isolation and Structure Elucidation of Novel Neuronal Cell Protecting Substances, Carbazomadurins A and B Produced by Actinomadura madurae.

-Ongoing screening for substances protecting central nervous system from glutamate toxicity leads to the discovery of the title compounds (I). Both substances suppress effectively the toxicity of L-glutamate in N18-RE-105 cells with EC 50 values of 97 nM and 84 nM, respectively. -(KOTODA, N.;

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