Total Synthesis of the Naphthyridine Alkaloid Jasminine.
β Scribed by M.-Lluisa Bennasar; Tomas Roca; Ester Zulaica; Manuel Monerris
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 8 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The oneβpot reaction of 4βbenzylpyridineβ3βcarbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.
Neozeylanicine I Alkaloid I 2,7-Naphthyridine I Isoquinolines 1 Electrocyclic reactions The 2,?-naphthyridine alkaloid neozeylanicine (6) was prepared starting from 3-bromo-4-picoline (1) by side-chain methoxycarbonylation, Pd-catalyzed ring acetylation and onepot ring anellation in 32% overall yie