First Total Synthesis of the 2,7-Naphthyridine Alkaloids Lophocladine A and B

✍ Scribed by Matthias Lotter; Johannes Schilling; Eberhard Reimann; Franz Bracher

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 298 KB
• Volume: 339
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200600134

✦ Synopsis

Abstract

The one‐pot reaction of 4‐benzylpyridine‐3‐carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.