Total Synthesis of the Cytotoxic 1,10-seco-Eudesmanolides Britannilactone and 1,6-O,O-Diacetylbritannilactone
✍ Scribed by Dr. Jörn Merten; Dr. Yuzhou Wang; Dr. Tilo Krause; Dr. Olga Kataeva; Prof. Dr. Peter Metz
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 182 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0947-6539
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📜 SIMILAR VOLUMES
A solution of [Ru,(CO),,] (200 mg. 0.32 mmol) and freshly distilled diazocyclopentadieiie [I31 (30 pL. 0.5 mmol) in dried T H F (40 mL) was heated at reflux under nitrogen lbi irnc hour. After evaporation of the solvent. thin-layer chromatography (SiO?) of Ihc orange-rcd residue. eluting with pentan
## Abstract Using a sultone as the key intermediate, the first enantioselective total synthesis of the antileukemic 1,10‐__seco__‐eudesmanolides (–)‐eriolanin (**1**) and (–)‐eriolangin (**2**) was achieved, which also established the hitherto unknown absolute configuration of these sesquiterpene l