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Total Synthesis of the Cytotoxic 1,10-seco-Eudesmanolides Britannilactone and 1,6-O,O-Diacetylbritannilactone

✍ Scribed by Dr. Jörn Merten; Dr. Yuzhou Wang; Dr. Tilo Krause; Dr. Olga Kataeva; Prof. Dr. Peter Metz


Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
182 KB
Volume
17
Category
Article
ISSN
0947-6539

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## Abstract Using a sultone as the key intermediate, the first enantioselective total synthesis of the antileukemic 1,10‐__seco__‐eudesmanolides (–)‐eriolanin (**1**) and (–)‐eriolangin (**2**) was achieved, which also established the hitherto unknown absolute configuration of these sesquiterpene l